BME250L: Molecular Biomechanics Laboratory

Laboratory course taken in conjunction with course 250. Students address a current scientific question about molecular motor function using techniques established in the UCSC Nanopore Laboratory. Specifically, students use recombinant DNA technology to produce an enzyme (e.g., a DNA polymerase) bearing a point mutation that is predicted to alter function in a defined manner. Students then use nanopore force spectroscopy to model the energy landscape for a mechanical or chemical step altered by the critical amino acid. Cannot receive credit for this course and course 150L. Concurrent enrollment in course 250 required. Enrollment restricted to graduate students. M. Akeson

2 Credits

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